Sell 6-bromoandrostenedione

6-bromoandrostenedione You May Also Be Interested In: 6 bromo androstane 3,17 dione 6 bromoandrostenedione
Chemical Name: 6-Bromo androstane-3,17-dione
Assay: 97%
A selective inhibitor of aromatase (estrogen synthetase) would be a useful pharmacological tool with potential therapeutic application. We have found that 6 alpha-bromoandrostenedione (6 alpha-BrA) is a competitive inhibitor of human placental aromatase with respect to androstenedione, with an apparent Ki of 3.4 nM, while 6 beta-BrA is a mechanism-based irreversible inhibitor with an apparent Ki of 0.8 microM and a kinact of 0.025 min-1. Aromatase activity was measured by tritium release into water from the 1 beta position of [1(-3) H,4(-14) C]androstenedione in reaction mixtures containing NADPH and the aromatase.