Andrographis paniculata extract
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andrographis paniculata extract
Bacopa monnieri Linn. Dry extract.
English name: Thyme leaved gratiola
Part used: Whole plant
Traditional uses 1-3: It is astringent, bitter and cooling and is reported to improve the intellect. It is used in the treatment of asthma, hoarseness, insanity, epilepsy and as a potent nerve tonic, cardiotonic and diuretic. It has been reported to be an anti-anxiety agent having adaptogenic effect. The leaves are also useful as diuretic and aperient. The juice of the leaves is given to children for relief in bronchitis and diarrhoea.
Phytochemistry: The major bioactive constituents of Bacopa monnieri are tetracyclic triterpenoid saponins, having pseudojujubogenin and jujubogenin aglycones. Among these, bacoside A (a crystalline mixture of several saponins) is predominant. The individual saponins reported from B. monnieri includes bacoside A1, A2 and A3, bacopasaponins A, B, C, D, E and F, and bacopaside I and II ds viz. , herpestine and brahmine; flavonoids viz. , luteolin-7-glucoside, glucoronyl-7-apigenin and glucoronyl-7-luteolin; common phytosterols 3-7.
Pharmacology: Bacopa monnieri has been proved to have memory enhancing6-9, sedative13, antiepileptic11 activity. Bacopa monnieri is also reported for its antispasmodic13 and anticancer11,12 activity. In addition it is evaluated for its cardiotonic10,13,14 and hypotensive10 activity.
Marker constituent: Bacoside A (mixture of several saponins with bacoside A3 as one of the components) .
Main use: Memory / Cogniton enhancer.
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3. Anonymous. (1998) The Wealth of Asia, Council of Scientific and Industrial Research. New Delhi, India.
4. Chakravarty AK, Sarkar T, Masuda K, Shiojima K, Nakane T, Kawahara N. (2001) Phytochemistry, 58: 553-556.
5. Anonymous. (1998) Indian Herbal Pharmacopoeia, Joint Publication of Indian Drug Manufacturer's Association, Mumbai and Regional Research Laboratory, Jammu-Tawi. 1: 30-37.
6. Singh HK, Dhawan BN. (1982) J. Ethnopharmacol. 5: 205-214.
7. Singh HK, Dhawan BN. (1997) Indian J. Pharmacol. 29: S359-S365.
8. Dubey GP, Pathak SR, Gupta BS. (1994) Pharmaco. Psycho. Ecologic. 7(3) : 249-251.
9. Sharma R, Chaturvedi C, Tewari PV. (1987) Jour. Res Edu Ind. Med. 3: 1-10.
10. Malhotra CL, Das PK. (1959) Ind. Jour. Med. Res. 47(3) : 294-305.
11. Elangovan V, Govindasamy S. (1995) Fitoterapia. 66(3) : 211-215.
12. Kumar EP, Elshurafa AA, Elango K, Subburaju T, Suresh B. (1998) Ancient Sci. Life. 17(3) : 228-234.
13. Aithal HN, Sirsi M. (1961) Indian J. Pharm. 23(1) : 2-5.
14. Dar A, Channa S. (1997) Phytother. Res. 11: 323-325.