Sell Andrographis paniculata extract

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Andrographis paniculata Nees.
Dry extract.

English name: King of Bitters, The Creat
Family: Acanthaceae
Part used: Leaves.

Traditional uses 1,2: The herb is reported to possess astringent, anodyne, tonic and alexipharmic properties and is helpful in dysentery, cholera, diabetes, influenza, bronchitis, piles, gonorrhoea, hepatomegaly, skin disorders, fever and worm infestation. The plant is bitter, acrid, cooling, laxative, vulnerary, antiperiodic, anti-inflammatory, expectorant, depurative, digestive and stomachic. It is useful in burning sensation, wounds, ulcers, chronic bronchitis, leprosy, pruritis, flatulence, colic and diarrhoea

Phytochemistry: The major bioactive chemical constituents of Andrographis paniculata are diterpene lactones. Among these, major constituent is andrographolide and minor constituents include neoandrographolide, 14-deoxy-11,12-didehydroandrographolide, andrograpanin3 andrographiside and many other closely related diterpenes4. The leaves contain flavonoids viz. , oroxylin, wogonin, andrographidines5 A, B, C, D, E, and F.

Pharmacology: Andrographis paniculata has been evaluated for different pharmacological activities. Andrographis paniculata has been reported for its potent hepatoprotective6,7. Andrographis paniculata has been reported to have antisecretory8 (antidiarrhoeal) , immuno stimulant9, antimalarial10, antifilarial11 activity. It is also reported to have anti cancer12, anti HIV13, anti-inflammatory14, hypotensive15 action. In addition, it has found to be effective in myocardial infraction16.

Marker constituents: Andrographolide, 14-deoxy-11, 12-didehydroandrographolide, Andrograpanin and

Main use: Hepatoprotective.


1. Anonymous. (1998) The Wealth of Asia, Council of Scientific and Industrial Research. New Delhi.
2. Warrier PK, Nambiar VPK, Ramankutty C. (1993) Indian Medicinal Plants a Compendium of 500 species, Orient Longman Ltd. , Madras, India, 1: 135-138.
3. Fujita T, Fujitani R, Takeda Y, Takaishi Y, et al. ( 1984) Chem. Pharm. Bull. 32: 2117-2125.
4. Matsuda T, Kuroyanagi M, Sugiyama S, Umehara K, Ueno A, Nishi K. (1994) Chem. Pharm. Bull. 42(6) : 1216-1225.
5. Anonymous. (1998) Indian Herbal Pharmacopoeia, Joint Publication of Indian Drug Manufacturer's Association, Mumbai and Regional Research Laboratory, Jammu-Tawi. 1: 18-29.
6. Visen PKS, Shukla B, Patnaik GK, Dhawan BN. (1993) J. Ethnopharmacol. 40(2) : 131-136.
7. Kapil A, Koul IB, Banerjee SK, Gupta BD. (1993) Biochem. pharmacol. 46(1) : 182-185.
8. Gupta S, Yadava JNS, Tandon JS. (1993) Int. J. Pharmacog. 31(3) , 198-204.
9. Puri A, Saxena R, Saxena RP, Saxena KC, Srivastava V, Tandon JS. (1993) J. Nat. Prod. 56(7) : 995-999.
10. Misra P, Pal NL, Guru PY, Katiyar JC, Srivastava V, Tandon JS. (1992) Int. J. Pharmacog. 30(4) : 263-274.
11. Dutta A, Sukul NC. (1982) J. Helminthol. 56:81-84.
12. Umehara K, Tatefuji T, Kuroyanagi M, Takagi R, Sugawa A, Ueno A, Taki T. (1990) J. Phar. Bio-Dyn. 13(3) : S51
13. Yao XJ, Wainberg MA, Parniak MA. (1992) Virology, 187: 56-62.
14. Madav S, Tripathi HC, Tandan, Mishra SK. (1995) Indian J. Pharm. Sci. 57(3) : 121-125.
15. Zang CY, Tan BK. (1996) Clin. Exp. Pharmacol. Physiol. 23(8) : 675-678.
16. Hua-yne Z, Wei-yi F. (1991) Chin. Med. J. 104(9) : 770-775.
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