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DL-Tetrahydroberberine is racemic form that hydrided from natural Berberine. It contains two optical isomers. Currently, severals of domestic and international research institutions worked together for many years for finding a kind of antiarrhythmic drug that is hydrogenated berberine as the precursors.
A kind of antiarrhythmic drug derived from Canadine with proprietary intellectual property rights will be used for clinical purposes soon.
The products derived from the active ingredients of natural plant Coptis chinensis Franch, Phellodendron amurense Rupr, Corydats yabhusuo W. T. Wang and Berberis julianae Schneid. .
Trade Name: Canadine [ (R) -canadine (S) -Canadine ]
CAS No. : 5096-57-1 114308-22-4 29074-38-2
Chemical Name: DL-Tetrahydroberberine DL-Canadine, (d, l) -Tetrahydroberberine (d, l) - Canadine
Molecular Formula: C20H21NO4
Molecular Weight : 339.39
Molecular Structure :
Cannadine >= 90%-98%
Appearance light yellow-needle crystal
Melting Point 166-1690C
Loss on drying <= 1.0%
Arsenic <= 2ppm
Heavy Metal <= 10ppm
Ignition Residual <= 0.5%
Microorganism <= 100 cfu/g
The date of 1H NMR
δ : 6.95 (1H, s)
6.91 (1H, d, J = 7.5 Hz) 6.80 (1H, d, J = 7.5 Hz)
6.64 (1H, s)
5.95 (2H, s)
3.86 (3H, s) 3.83 (3H, s)