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Cefotaxime generally is less active in vitro against susceptible staphylococci than first generation cephalosporins but has an expanded spectrum of activity against gram-negative bacteria compared with first and second generation cephalosporins

7 Gram-positive Aerobic Bacterial Infections

Cefotaxime is used in the treatment of lower respiratory tract infections caused by susceptible Streptococcus pneumoniae, S. pyogenes (group A b-hemolytic streptococci) , other streptococci (except interococci) , or Staphylococcus aureus; genitourinary tract infections caused by susceptible S. aureus, S. epidermidis, or enterococci; gynecologic infections caused by susceptible S. epidermidis or streptococci (including enterococci) ; skin and skin structure infections caused by suscepptible S. aureus, S epidermidis, group A b-hemolytic streptococci, or other streptococci (including enterococce) ; intra-abdominal infections caused by susceptible streptococci; or bone and joint infections caused by susceptible S. aureus, , group A b-hemolytic streptococci, or other streptococci. Cefotaxime generally should not be used in the treatment of infections caused by gram-positive bacteria when a penicllin or a first generation cephalosporin could be used