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Product Name: Daidzein 98%HPLC; . M. F. :C15 H10O4. CAS. RN. NO:486-66-8. genistein, daidzein and glycetin, Da Dou. phytoestrogens, soy isoflavone products, soy isoflavone aglycones, soy phytoestrogens, Genistein mimics human estrogens Serie No: S-033
Place of Origin: China Brand Name: MDidea Extracts Professional
Quality/Safety Certifications:GMP Price Terms:EXW, CNF, CIF.
Minimum Order:1~25kilos Payment Terms:Transfer.
Delivery Lead Time:1~3 days Supply Ability:500kilos+
Daidzein 98%HPLC; . M. F. :C15 H10O4. CAS. RN. NO:486-66-8. genistein, daidzein and glycetin, Da Dou. phytoestrogens, soy isoflavone products, soy isoflavone aglycones, soy phytoestrogens, Genistein mimics human estrogens
Botanical Source:Soybeans, Glycine max, Glycine soja , Soya, Beans
. . . . . . . . Common Names&Synonyms:genistein, daidzein and glycetin, Da Dou. phytoestrogens, soy isoflavone products, soy isoflavone aglycones, soy phytoestrogens, Genistein mimics human estrogens
Introduction and Brief Benefits of Soy Isoflavones:
Isoflavones are polyphenolic compounds that are capable of exerting estrogen-like effects. For this reason, they are classified as phytoestrogens, compounds with estrogenic activity derived from plants. Legumes, particularly soybeans, are the richest sources of isoflavones in the human diet. In soybeans, isoflavones are present as glycosides (bound to a sugar molecule) . Fermentation or digestion of soybeans or soy products results in the release of the sugar molecule from the isoflavone glycoside, leaving an isoflavone aglycone. Soy isoflavone glycosides are called genistin, daidzin, and glycitin, while the aglycones are called genistein, daidzein, and glycitein, respectively (chemical structures of isoflavone aglycones) . Unless otherwise indicated, quantities of isoflavones specified in this article refer to aglycones, not glycosides.
Introduction and Brief Benefits of Soy Isoflavones:
Soy Isoflavones are derived from Soybeans. Isoflavones belong to a class of compounds known as flavonoids. The highest amounts of Isoflavones can be found in soy nuts and tempeh. Isoflavones are fairly stable; they are not destroyed under normal cooking methods. Soy Isoflavones is a promising nutraceutical with potentially significant health benefits.
Benefits of using Soy Isoflavones :
Soy isoflavones provide beneficial effects for the prevention and treatment of breast, colon and prostate cancers.
Soy isoflavones are also known as phytoestrogens (plant estrogens) , signifying their mild estrogenic activity.
Soy isoflavones reduce the bioavailability of sex hormones that may stimulate tumor growth capacity in both men and women.
Soy isoflavones are beneficial in preventing osteoporosis and autoimmune conditions.
Special soy isoflavones supplements are also available in capsules and tablets. Some provide added digestive enzymes.
Properties of Isoflavones:
Phyto-estrogens are dietary nonsteroidal plant compounds of diverse structure that produce estrogenic responses. They vary greatly in both their potency and physiological effects. There are three main classes of phyto-estrogens: isoflavones, coumestans and lignans, which are present in either plants or their seeds. Isoflavones in four chemical forms: the aglycons daidzein, genistein and glycitein; the glucosides daidzin, genistin and glycitin; the acetyiglucosides and the malonylglucosides. Isoflavones are structurally similar to the mammalian estrogen, estradiol. The principal compounds within these classes of phyto-estrogens have been shown to have weak estrogenic activity, ranging from 0.002 to 0.001 the activity of estradiol. Their effect can both be agonistic and antagonistic to 17-Beta estradiol when they act simultaneously at target tissues. Antagonistic compounds normally compete for 17-Beta estradiol receptors but fail to exert a similar estrogenic effect.
Health Effects of Isoflavones:
The above raises the interest in isoflavones as protective agent for hormone-related diseases, as menopause, osteoporosis and coronary heart disease and breast cancer.
The hot flush is the most common and disruptive symptom of the menopause. Estrogen replacement therapy eliminates 60% of flushes within three months. Hormone replacement generally alleviates the condition, as well as the vaginitis occurring at the menopause due to atrophy. However, due to increasingly suggested and reported negative side effect of hormone replacement therapies, women today request dietary and natural' options for symptom management. The rarity of the problem in soy consuming countries has prompted some investigations to determine whether phyto-estrogens have a similar effect. Human studies have shown that soy isoflavone supplementation resulted in significant reduction in the frequency and intensity of hot flushes and increases serum levels of SHBG, which in turn may alleviate symptoms such as hot flushes and vaginal dryness.
Osteoporosis in women is particularly associated with menopause, since the loss of estrogen accelerates bone loss. The hormonal effect of phyto-estrogens, coupled with the comparative rarity of the disease in populations consuming soy, has also prompted investigation of their effects on osteoporosis. Dietary effects have been investigated for achieving peak bone mass and preventing bone loss in later life. It has even been showed that isoflavones do not only prevent the loss of bone, but even allow significant increases in both mineral content and bone mineral density in the lumbar spine region. Similar trends were notes for other skeletal areas. An important role in this effect is ascribed to daidzein. More human studies are currently conducted.
Coronary Heart Disease (CHD) The importance of lowering serum cholesterol in reducing the risk of CHD, and total mortality, is now well established. As CHD is a multi-factorial disease, many dietary factors are involved in affecting risk. LDL-lipoproteins are normally taken up by the liver, thus maintaining levels of serum cholesterol, but if they are oxidatively damaged they are taken up by macrophages to form foam cells in the lining of arteries, initiating the first stages of atherosclerosis. In soy, the positive role of soy proteins is strongly recognised. The Food and Drug Administration in the US has approved a health claim for cholesterol lowering effect when consuming 25g of soy protein per day. The isoflavones may prevent oxidative damage through their antioxidant activities, and are believed to support an improved HDL/LDL ratio. Furthermore because of its effects on tyrosine kinases, genistein may have a role in suppression of the cellular processes which lead to atherosclerosis.
High soy consumption leading to high exposures of soy isoflavones has been associated with a reduced risk of cancers at many sites. Several studies on experimental animals and cell cultures have demonstrated cancer chemo-preventive effects of soy isoflavones. In addition to weak estrogenic activities, isoflavones possess a variety of characteristics such as antioxidant, anti-proliferative and differentiation-inducing abilities. A recent study shows that isoflavones might also increase the metabolism of endogenous estrogens to the protective 2-hydroxylated estrogens in women, and this may play an important role in lowering 1 7Beta-estradiol levels and the long-term risk for breast cancer. Also the role of the immune function has become increasingly important in our understanding of the mechanisms underlying the body's ability to prevent cancer. At high doses, especially daidzein was shown to enhance several immuno-regulatory functions.
Diet derived health protectants, like the isoflavones, need sufficient systemic bio-availability to exert the beneficial effects. Determinants of isoflavone bio-activity are structural differences between the isoflavones, gut micro-floral metabolism and mammalian phase-II metabolism. Gut micro-floral influences seems a major factor in inter-individual variation in isoflavones blo-availability. Individuals who excrete larger amounts of faecal isoflavones have much higher urinary and plasma isoflavone levels than individuals who excrete small amounts of isoflavones in faeces. Moreover, these high excreters experience more prolonged plasma diadzein and genistein. Research has shown that glycitein and daidzein are more blo-available than genistein. Urinary recovery of glycitein and daidzein was about 47% and 52% respectively after a single soy dose, whereas the recovery of genistein was 37%. Genistein's lower bio-availability may be due to its more rapid degradation in the gut compared with daidzein and glycitein.
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specifications and supplying conditions:
Content Standardized: Soy Bean isoflavones 40%HPLC Genistein80~98%HPLC Daidzein 98%HPLC
Serie Code: S33. M05.
Expiration Date: 18~24Months in Good Condition
Storage Stock: Bulk in Stock
Pricing Terms: C&F; CIF; DDU; DDP.
Delivery Arrange: Soonest on the Day Confirmed
Appearance Showing: Yellow Fine Powder to White Powder
Extracts State: Fine Crystal Powder
Mesh Size: 100% Pass 80 Mesh Screen
Color: Yello or light Yellow(Soy Isoflavones) or Similar Light Yellow White to White Powder(Genistein)
Odor and Smell: Charateristics
Taste Sense: Flavour with Characteristics
Bulk Density: 0.40~0.50g/ml.