FSH - follicle stimulating hormone test
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follicle stimulating hormone
follicle stimulating hormone test
Follicle stimulating hormone (FSH) or follitropin is a gonadotropin in the family of pituitary hormones secreted by pituitary in normal men and women. The function of FSH is to regulate the early development of the ovarian follicle in the female and initial steps of spermatid maturation in the male. FSH is structurally related to certain other pituitary and placental hormones including human chorionic gonadotropin (hCG) , human thyroid stimulating hormone (hTSH) , and human lutenizing hormone (hLH) .
In Women, FSH stimulates the growth and maturation of ovarian follicles during the menstrual cycle. During the menstrual cycle the FSH level varies in response to the changes of estradiol and progesterone. Shortly before ovulation, a significant rise in FSH and LH can be observed. After ovulation, the follicle is returned, an egg is released and the developed corpus luteum then secretes estradiol and progesterone, which decrease the levels of FSH and LH back to the lower levels.
Prior to the onset of menopause, ovarian function and estradiol secretion diminish and circulating FSH level rise significantly as a result of removal of the negative feedback control on the hypothalamus. Menopause is clinically defined as 12 months after cessation of the menstrual flow.
FSH is present in blood and excreted in the urine. The concentration of FSH in urine correlates with FSH levels present in serum. In women with normal menstrual cycles, the levels of FSH fluctuate during the cycle with peak levels on an average of approximately 25mIU/ml occurring at the menstrual mid-cycle. As a woman approaches to and goes through menopause, the level of FSH surges to an average of approximately 110mIU/ml and can reach as high as 500mIU/ml.
The Chemtrue. One-Step FSH Menopause Test is a rapid chromatographic immunoassay that can detect FSH surges in urine above 25mIU/mL, a median concentration achieved at the midpoint of the menstrual cycle. The test is intended for use in detecting FSH surges as one of the prognosis factors for the evaluation of the onset of menopause equivalent to surge levels.