Flaxseed Lignans extract
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flax seed oil
Linum Usitatissimum L.
Part of Plant Used
Lignans are one of the two major classes of phytoestrogens (the other class is the isoflavones) . Lignans are classified as phytoestrogen since they are plant-derived, non-steroid compounds that possess estrogen-like activity.
In recent years there has been increased interest in the effect of flax seed components on human health. Although much of this interest has focused on the effects of the omega-3 fatty acids present in high levels in flax seed oil, there has been increasing interest in the non-oil components, particularly the lignan fraction. This interest has been driven by the observation that the flax lignan, secoisolariciresinol diglucoside (SDG) .
SDG is the precursor of the major mammalian lignans, enterodiol (EL) and enterolactone (ED) . In another words, EL and ED is metabolites of SDG.
Studies showed SDG had estrogenic and antioxidant activities, also had anticarcinogenic, antiatherogenic and antidiabetic activities.
SDG was claimed to be effective in reducing hypercholesterolemic atherosclerosis oxidative stress and lowering serum levels of cholesterol and low-density lipoprotein-cholesterol and raising serum levels of high-density lipoprotein-cholesterol. Additionally, low serum enterodiol concentration in man has been associated with enhanced lipid peroxidation in vivo and might, therefore, be a risk factor for cardiovascular disease. Dietary supplementary with SDG was shown to be effective in inhibiting the development of type-1 and type-2 diabetes. With respect to cancer, EL and ED have been shown to exert anticarcinogenic properties. Moreover, in epidemiological studies, they have been associated with a reduced cancer risk. Supplementary SDG has shown positive effects on the early markers of colon carcinogenesis, on the initial and promotional stages of mammary tumorigenesis in rats, on the pulmonary metastasis of melanoma cells in mice.