Sell Gymnema sylvestre Extract.5:1, Gymnema Acid7.5%HPLC~25%HPLC. CAS. RN. NO:1399-64-0

Gymnema sylvestre Extract.5:1, Gymnema Acid7.5%HPLC~25%HPLC. CAS. RN. NO:1399-64-0 You May Also Be Interested In: gymnema leaves gymnema sylvestre gymnema sylvestre extract leaf plant quinine
Product Name: Gymnema sylvestre Extract.5:1, Gymnema Acid7.5%HPLC~25%HPLC. CAS. RN. NO:1399-64-0 Serie No: R-009
Place of Origin: China Brand Name: MDidea Extracts Professional
Quality/Safety Certifications:GMP Price Terms:EXW, CNF, CIF.
Minimum Order:1~25kilos Payment Terms:Transfer.
Delivery Lead Time:1~3 days Supply Ability:500kilos+



Gymnema sylvestre Extract.5:1, Gymnema Acid7.5%HPLC~25%HPLC. CAS. RN. NO:1399-64-0
. . . . . . . . Botanical Source:Gymnema sylvestre, Gymnema sylvestre Roxb.
. . . . . . . . Common Names&Synonyms:Ram''''s Horn, Gurmar, Meshashringi, Gurmarbooti, Gurmar. Gymnemic acid, Standardisation of Gymnema sylvestre r. Br. , Gymnema sylvestre leaf extract, Gymnema montanum leaves extract,


Phytochemicals and Structure of Gymnema sylvestre(urmarbooti, Gurmar) :

Gymnema leaves contain Gymnemic acid as an effective substance. Gymnemic acid has a structure with tri-terpenoid combined with glucuronic acid and several fatty acids. We have established analytical method of Gymnemic acid by HPLC method, and extract and refine Gymnema syrvestre extract with a clear guideline of effective substance.
Phytochemicals:
The primary chemical constituents of Gymnema include Gymnemic acid, tartaric acid, gurmarin, calcium oxalate, glucose, stigmasterol, betaine, and choline. While studies have shown that a water-soluble acidic fraction provides the hypoglycemic actions, it is not yet clear what specific constituent in the leaves is responsible for this action. Some researchers have suggested gymnemic acid as one possible candidate, however further research is needed. Both gurmarin (another constituent of the leaves) and gymnemic acid have been shown to block sweet taste in humans.
The hypoglycemic (blood sugar-lowering) action of gymnema leaves was first documented in the late 1920s. This action is gradual in nature, differing from the rapid effect of many prescription hypoglycemic drugs. Gymnema leaves raise insulin levels, according to research in healthy volunteers. Based on animal studies, this may be due to regeneration of the cells in the pancreas that secrete insulin. Other animal research shows that gymnema can also improve uptake of glucose into cells and prevent adrenaline from stimulating the liver to produce glucose, thereby reducing blood sugar levels.
The presence of Gymnemic acid (GA) , (+) quercitol, lupeol, Alpha-Amyrin, stigmasterol etc. , have been reported. GA I, II, III and IV are anti sweet substance from the leaves of G. sylvestris. They all contain a glucuronic acid moiety, and the gymnemagenin aglycone esterified at position C-21 and C-28. A second series of Gymnemic acid V-VII has also been reported. GA VII is the 3-O-glucuronide of gymnemagenin and GA V is the O-3-glycuronyl- 22, 21-bis-O-tigloyl substitution pattern. GA VIII-IX are also esters of saponin, have an oxoglycoside moiety attached to the glucuronic acid residue. Gurmarin, another constituent of the leaves, and gymnemic acid have been shown to block sweet taste in humans. Some researchers have suggested gymnemic acid as one possible candidate responsible for antidiabetic activity.
Molecular Structure of Gymnemic acid:

How Gymnema sylvestre Works:

Recent pharmacological and clinical studies have shown that Gymnema sylvestre acts on two sites:
First, the taste buds in the oral cavity;
Second, the absorptive surface to the intestines.
The structure of those taste buds which detect sugar in the mouth is similar to the structure of the tissue that absorbs sugar in the intestine. The important active ingredient of Gymnema sylvestre is an organic acid called "gymnemic acid. " The gymnemic acid is made up of molecules who seatom arrangement is similar to that of glucose molecules. Those molecules fill the receptor locations on the taste buds for a period of one to two hours, thereby preventing the taste buds from being activated by any sugar molecules present in the food. Similarly, the glucose-like molecules in the gymnemic acid fill the receptor locations in the absorptive external layers of the intestine, thereby preventing the intestine from absorbing the sugar molecules.
It has also been noted that Gymnema sylvestre takes away the bitter taste of bitter substances, such as quinine, in much the same way that it affects the sense of sweetness associated with candies and other sweet foods. However, it has no effect on pungent, salty, astringent or acidic tastes. Therefore, if you are eating an orange within two hours after chewing Gymnema sylvestre leaves, for instance, you would taste the sourness of it but not the sweetness.


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Dosage and Administration:

In human studies, the most common doses of gymnema sylvestre used for blood sugar control were 400 mg to 600 mg per day. Gymnema sylvestre is commonly added to many different herbal combination products, but the majority of studies used GS4, a standardized product that contains only gymnema sylvestre. Standardization by the manufacturer should assure the same amount of active ingredient in every batch of the commercial preparation. Standardization of herbal products is not required by the U. S. Food and Drug Administration (FDA) , so not every product will contain the same amounts of active ingredients.

Indications or Mechanism Note:
The important active ingredient of Gymnema sylvestre is an organic acid called ?!cgymnemic acid. ?!@ The gymnemic acid is made up of molecules whose atom arrangement is similar to that of glucose molecules. The glucose-like molecules in the gymnemic acid fill the receptor locations in the absorptive external layers of the intestine, thereby preventing the intestine from absorbing the sugar molecules. The direct evidence is that sugar taste no longer sweet when took with the gymnema. Gymnema sylvestre significantly reduces the metabolic effects of sugar by preventing the intestines from absorbing the sugar molecules during the process of digestion. Because there is a change in the absorption of sugar, there is a consequent change in the blood sugar level. Also, it has been shown in clinical trials to assist regeneration of the insulin-producing Beta Cells, thus reduces prescription insulin requirements for those diabetics who actively monitor blood sugar levels.

Products Specifications and Supplying Conditions:

Description: Gymnema sylvestre P. E. (Gurmar leaf P. E. )
Plant Part Used: Gurmar leaf, plant of Gymnema sylvestre
Extract Ratio: 5:1/15:1 TLC
Serie Code: R-009
Expiration Date: 18~24Months in Good Condition
Storage Stock: Bulk in Stock
Pricing Terms: C&F; CIF; DDU; DDP.
Delivery Arrange: Soonest on the Day Confirmed
Appearance Showing: Greenish Yellow Fine Powder
Extracts State: Fine Crystal Powder
Mesh Size: 100% Pass 80 Mesh Screen
Color: Greenish Yellow
Odor and Smell: Charateristics
Taste Sense: Flavour with Characteristics
Bulk Density: 0.45g/ml.