Sell K-ras Mutation Test Kit

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"Amoy Diagnostics has developed a series of first-in-class cancer test kits It is utilizes Real-time PCR to detect gene mutations, thus aiding doctors and pharmaceutical companies in determining appropriate treatments and therapies for patients.

K-ras Mutation Test Kit
Amoy Diagnostics has developed a series of first-in-class test kits for cancer patients based on the company newly patented technology platform. These reagents are designed for detecting gene mutation products in cancer cells with the intention of aiding doctors and drug companies in selecting treatments and therapies for patients.

ADx  K-ras Mutation Test Kit
The molecular diagnostic kit is used to aid physicians in identifying colorectal cancer patients who may not benefit from anti-EGFR therapies Erbitux (cetuximab) or Vectibix (panitumumab)

Clinical studies indicate that these mutations are linked to cancer prognosis and chemotherapy resistance. Recent studies have shown that efficacy of Erbitux or Vectibix in metastatic colorectal cancer (mCRC) is confined to patients with non-mutated K-RAS. However, patients who have mutant forms of the KRAS gene in their tumors will not respond to Erbitux or Vectibix therapy. It is, therefore, very important to test
mutations in the K-ras gene before starting Erbitux or Vectibix therapy.

Key features:
-Produces results in <90min
-Works with fresh , frozen, or paraffin embedded tissue, and blood or serum specimens
-The reagent (Real-time PCR kits) is based on the patented technology of probes
-High levels of accuracy and precision
-Can detect 0.1%-1% of mutant in a background of wild-type genomic DNA
-For Research Use Only

1. Amado R G, Wolf M, Peeters M, Van Cutsem E et al. Journal of Clinical Oncology. April2008
2. Van Cutsem et al. ASCO Annual Meeting 2008:abstract2.
3. Bokemeyer et al. ASCO Annual Meeting 2008:abstract 4000.