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CAS NO. 128794-94-5
MOL WT. 433.49
H. S. CODE
SYNONYMS Mycophenolic acid 2-morpholinoethyl ester;
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5- isobenzofuranyl) -4- methyl-, 2-(4-morpholinyl) ethyl ester; 2-Morpholinoethyl (E) -6-(l,3-dihydro-4-hydroxy-6- methoxy-7- methyl-3- oxo-5-isobenzofuranyl) -4- methyl-4-hexenoate
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE White to off-white crystalline powder
SOLUBILITY IN WATER
STABILITY Stable under ordinary conditions.
Mycophenolate, 2-morpholinoethyl ester of mycophenolic acid, is a guanine monophosphate synthesis inhibitor by interfering with the synthesis of inosine mononophosphate dehydrogenase (IMPDH) , resulting in inhibiting the proliferation of cells, especially leukocytes and lymphocytes. It is more lymphocyte-specific than azathioprine. Mycophenolate is an immunosuppressive agent used in conjunction with cyclosporine and corticosteroids to prevent rejection of allogeneic renal transplants. Mycophenolate mofetil is a white to off-white crystalline powder; soluble in acetone and methanol, and sparingly soluble in water and ethanol; administered orally. The chemical designation is 2-morpholinoethyl (E) -6-(l,3-dihydro-4-hydroxy-6-methoxy-7- methyl-3-oxo-5-isobenzofuranyl) -4- methyl-4-hexenoate.
White to off-white crystalline powder
97.5 - 100.5%
LOSS ON DRYING
HEAVY METALS 20ppm max
RELATED SUBSTANCES 1.0% max (FREE ACID: 0.5 max)
GENERAL DESCRIPTION OF IMMUNOSUPPRESSIVE DRUGS
Immunosuppressants are drugs to prevent transplant rejection after organ transplantation by inhibiting the reaction of the immune system and suppression of body's ability to recognize and destroy foreign substances. But they also reduce the ability of the immune system to fight infections, resulting in vulnerable body to opportunistic infections and risk of developing certain cancers. Most of immunosuppressants suppress the whole immune system. Globulin types used in combination with other immunosuppressants and monoclonal antibodies suppress specific parts of the immune system. Immunosuppressions are also used to counteract autoimmune diseases characterized by an overactive immune response, whereby the body own immune defense mechanisms are inappropriately directed against the normal tissue that lines the joints and connective tissue in many other parts of the body, such as the blood vessels and lungs, resulting in organ damage or activation of a systemic immune response. Immunosuppressive drugs can be classified into groups as follows:
Tumor necrosis factor (TNF) inhibitors