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Natamycin is a polyene macrolide antibiotic produced by submerged aerobic fermentation of Streptomycesnatalensis and related species. Fermentation is conducted for several days, and the antibiotic is isolated either by broth extraction or by extraction of the mycelium. Its medical use is now confined to topical treatment of corneal fungal infections and the prevention of such infections in users of contact lens. As food preservative, Natamycin also can be used to prevent food from mold, spoilage.