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Orotic acid is a chemical overproduced in an alternative pathway when there is a block in the urea cycle. Excessive amounts of orotic acid are usually found in OTC (ornithine transcarbamylase) deficiency, citrullinemia, and oftentimes in argininosuccinic aciduria. Orotic acid determination is useful in delineating the cause of hyperammonemia.
Vitamin B13 is a compound from distillers consisting of dried solubles. It was later identified as orotic acid, an intermediate in pyrimidine metabolism. Orotic acid (OA) , a naturally occurring substance, is a key intermediate in the biosynthetic pathway of