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Shanghai Trifecta Pharma Ltds also is a leading supplier of Pravastatin and other Cardovasular API products.
Pravastatin sodium is one of a class of lipid-lowering compounds, the HMG-CoA reductase inhibitors, which reduce cholesterol biosynthesis. These agents are competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme catalyzing the early rate-limiting step in cholesterol biosynthesis, conversion of HMG-CoA to mevalonate.
Pravastatin sodium is designated chemically as 1-Naphthalene-heptanoic acid, 1,2,6,7,8,8a-hexahydro-b, d ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy) -, monosodium salt, [1S-[1a(bS*, dS*) ,2a,6a,8b(R*) ,8aa]]-. Structural formula:
Pravastatin sodium is an odorless, white to off-white, fine or crystalline powder. It is a relatively polar hydrophilic compound with a partition coefficient (octanol/water) of 0.59 at a pH of 7.0. It is soluble in methanol and water (>300 mg/mL) , slightly soluble in isopropanol, and practically insoluble in acetone, acetonitrile, chloroform, and ether.
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