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Function: Dioscorea root contains diosgenin, which has anti-fatigue, anti-inflammatory, anti-stress, hypocholesterolemic, and estrogenic effects. Dioscorea is antispasmodic, and could be helpful for nausea of pregnant women (morning sickness) , spasmodic hiccough and asthma. Most women experience lack of progesterone, not estrogen. Natural progesterone supplements are used to balance estrogen. Natural progesterone has a structure similar to that of human progesterone and is made form plant fats; one of such fats is diosgenin. Wild Yam is reach in diosgenin, so it became the most popular source of natural progesterone.